Medical science has been on an exponential growth for the past few years. Among many, a major effort is focused on creating lab-grown kidneys. Now, a hospital in Israel has achieved the breakthrough that marks a significant milestone in regenerative medicine.
Sheba Medical Centre along with the help of Tel Aviv University has successfully created a synthetic 3D organ culture or organoid that was the first to survive beyond 34 weeks, reported the South China Morning Post.
Earlier organoids had failed to survive even four weeks, said Benjamin Dekel, director of Sheba's paediatric nephrology unit and Stem Cell Research Institute.
Why does development matter?
According to Dekel, kidney organoids help researchers model kidney disease, making it easy for them to understand the underlying mechanisms and allowing timely interventions. This also aids in reducing the dependency of drug tests being conducted on mice.
He further expressed optimism over the research adding, "I'm very, very optimistic about the path forward. It doesn't involve cell transplantation, [but rather] the molecules [the organoid] secretes," can help repair injured kidneys.
Is there a possibility of clinical application?
He also underlined that translating the research into clinical application will take longer as "translating scientific discoveries into clinical applications takes time."
"Once we have a clear understanding of which cells to use, the biomolecules they secrete, and how they aid in kidney repair in adults, we can begin moving towards clinical translation," he added.
Sheba Medical Centre along with the help of Tel Aviv University has successfully created a synthetic 3D organ culture or organoid that was the first to survive beyond 34 weeks, reported the South China Morning Post.
Earlier organoids had failed to survive even four weeks, said Benjamin Dekel, director of Sheba's paediatric nephrology unit and Stem Cell Research Institute.
Why does development matter?
According to Dekel, kidney organoids help researchers model kidney disease, making it easy for them to understand the underlying mechanisms and allowing timely interventions. This also aids in reducing the dependency of drug tests being conducted on mice.
He further expressed optimism over the research adding, "I'm very, very optimistic about the path forward. It doesn't involve cell transplantation, [but rather] the molecules [the organoid] secretes," can help repair injured kidneys.
Is there a possibility of clinical application?
He also underlined that translating the research into clinical application will take longer as "translating scientific discoveries into clinical applications takes time."
"Once we have a clear understanding of which cells to use, the biomolecules they secrete, and how they aid in kidney repair in adults, we can begin moving towards clinical translation," he added.
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